Choose the word or set of words that, when inserted in the sentence, best fits the meaning of the sentence as a whole. 

In her review of a recent novel, the book reviewer insisted on discussing details of the author’s life, in open ------- the current trend in criticism, which eschews any consideration of biographical matters.

1.   fixation on
2.   defiance of
3.   deference to
4.   incitement of
5.   collusion with